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Selenoprotein P : ウィキペディア英語版 | Selenoprotein P
In molecular biology the protein domain SelP stands for selenoprotein P which is the only known eukaryotic selenoprotein that contains multiple selenocysteine (Sec) residues. It is a secreted glycoprotein, often found in the plasma. It's precise function remains to be elucidated however it is thought to have antioxidant properties. This particular protein contains two domains: the C terminal and N terminal domain. The N-terminal domain is larger than the C terminal and the N-terminal is thought to be glycosylated. ==Function== SelP may have antioxidant properties. It can attach to epithelial cells, and may protect vascular endothelial cells against peroxynitrite toxicity.〔 The high selenium content of SelP suggests that it may be involved in selenium intercellular transport or storage.〔 The promoter structure of bovine SelP suggests that it may be involved in countering heavy metal intoxication, and may also have a developmental function.
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